Frankie Liles has three losses against three opponents on his boxing record. For a list of Liles's best fights, refer to "Best fights of Frankie Liles".
On March 30, 2002 Frankie Liles faced off against Demetrius Jenkins in a light-heavyweight bout at age 37. He was coming in with a record of 32-3 (19). Liles lost the fight via 7th-round TKO.
On June 12, 1999 Frankie Liles faced off against Byron Mitchell in a super-middleweight bout at age 34. He was coming in with a record of 32-2 (19), and Mitchell was 25 years old and with a record of 19-0 (15). Liles lost the fight via 11th-round TKO.
On July 7, 1992 Frankie Liles faced off against Tim Littles in a super-middleweight bout at age 27. He was coming in with a record of 21-1 (14). Liles lost the fight via 12-round unanimous decision.