Frank Bruno has five losses against four opponents on his boxing record. For a list of Bruno's best fights, refer to "Best fights of Frank Bruno".
On March 16, 1996 Frank Bruno met Mike Tyson in a heavyweight (WBC) world-title defense fight. Bruno was 34 years old and with a record of 40-5 (38), and Tyson was 29 years old and with a record of 43-1 (37). Bruno lost the fight via 3rd-round TKO and lost the title.
On October 1, 1993 Frank Bruno fought Lennox Lewis in a heavyweight world-title fight for Lewis' WBC title. Bruno was 31 years old and with a record of 36-4 (35), and Lewis was 28 years old and with a record of 23-0 (19). Bruno lost the fight via 7th-round TKO.
On February 25, 1989 Frank Bruno fought Mike Tyson in a heavyweight world-title fight for Tyson's WBA, WBC, IBF and The Ring titles. Bruno was 27 years old and with a record of 32-3 (31), and Tyson was 22 years old and with a record of 35-0 (31). Bruno lost the fight via 5th-round TKO.
On July 19, 1986 Frank Bruno fought Tim Witherspoon in a heavyweight world-title fight for Witherspoon's WBA title. Bruno was 24 years old and with a record of 28-2 (27), and Witherspoon was 28 years old and with a record of 24-2 (16). Bruno lost the fight via 11th-round TKO.
On May 13, 1984 Frank Bruno faced off against James Smith at age 22. He was coming in with a record of 21-1 (21), and Smith was 31 years old and with a record of 13-1 (11). Bruno lost the fight via 10th-round KO.