Fernando Vargas has five losses against four opponents on his boxing record. For a list of Vargas's best fights, refer to "Best fights of Fernando Vargas".
On November 23, 2007 Fernando Vargas faced off against Ricardo Mayorga in a super-middleweight bout at age 29. He was coming in with a record of 26-5 (22), and Mayorga was 34 years old and with a record of 27-6-1 (22). Vargas lost the fight via 12-round majority decision.
On July 15, 2006 Fernando Vargas faced off against Shane Mosley at age 28. He was coming in with a record of 26-4 (22), and Mosley was 34 years old and with a record of 42-4 (36). Vargas lost the fight via 6th-round TKO.
On February 25, 2006 Fernando Vargas faced off against Shane Mosley at age 28. He was coming in with a record of 26-3 (22), and Mosley was 34 years old and with a record of 41-4 (35). Vargas lost the fight via 10th-round TKO.
On September 14, 2002 Fernando Vargas, the WBA champion, met Oscar De La Hoya, the WBC, WBA (Super) and The Ring champion, in a super-welterweight world-title unification fight. Vargas was 24 years old and with a record of 22-2 (20), and De La Hoya was 29 years old and with a record of 34-2 (27). Vargas lost the fight via 11th-round TKO and lost his title.
On December 2, 2000 Fernando Vargas, the IBF champion, met Félix Trinidad, the WBA champion, in a super-welterweight world-title unification fight. Vargas was 22 years old and with a record of 20-1 (18), and Trinidad was 27 years old and with a record of 38-0 (31). Vargas lost the fight via 12th-round TKO and lost his title.