Esteban de Jesús has five losses against four opponents on his boxing record. For a list of Jesús's best fights, refer to "Best fights of Esteban de Jesús".
On July 7, 1980 Esteban de Jesús fought Saoul Mamby in a super-lightweight world-title fight for Mamby's WBC title. Jesús was 28 years old and with a record of 58-5 (33). Jesús lost the fight via 13th-round TKO.
On January 21, 1978 Esteban de Jesús, the WBC champion, met Roberto Durán, the WBA and The Ring champion, in a lightweight world-title unification fight. Jesús was 26 years old and with a record of 52-4 (30), and Durán was 26 years old and with a record of 62-1 (51). Jesús lost the fight via 12th-round TKO and lost his title.
On May 17, 1975 Esteban de Jesús fought Antonio Cervantes in a super-lightweight world-title fight for Cervantes' WBA and The Ring titles. Jesús was 23 years old and with a record of 45-3 (25), and Cervantes was 29 years old and with a record of 47-9-1 (25). Jesús lost the fight via 15-round unanimous decision.
On March 16, 1974 Esteban de Jesús fought Roberto Durán in a lightweight world-title fight for Durán's WBA and The Ring titles. Jesús was 22 years old and with a record of 42-2 (23), and Durán was 22 years old and with a record of 41-1 (35). Jesús lost the fight via 11th-round KO.
On December 10, 1971 Esteban de Jesús faced off against Antonio Gomez at age 20. He was coming in with a record of 26-1 (18). Jesús lost the fight via 10-round unanimous decision.