Emmanuel Rodríguez has three losses against three opponents on his boxing record. For a list of Rodríguez's best fights, refer to "Best fights of Emmanuel Rodríguez".
On May 4, 2024 Emmanuel Rodríguez met Ryosuke Nishida in a bantamweight (IBF) world-title defense fight. Rodríguez was 31 years old and with a record of 22-3 (13), and Nishida was 27 years old and with a record of 8-0 (1). Rodríguez lost the fight via 12-round unanimous decision and lost the title.
On December 19, 2020 Emmanuel Rodríguez fought Reymart Gaballo in a bantamweight world-title fight for the WBC title. Rodríguez was 28 years old and with a record of 19-2 (12), and Gaballo was 24 years old and with a record of 23-0 (20). Rodríguez lost the fight via 12-round split decision.
On May 18, 2019 Emmanuel Rodríguez, the IBF champion, met Naoya Inoue, the The Ring champion, in a bantamweight world-title unification fight. Rodríguez was 26 years old and with a record of 19-1 (12), and Inoue was 26 years old and with a record of 17-0 (15). Rodríguez lost the fight via 2nd-round KO and lost his title.