Daniel Ponce de León has seven losses against six opponents on his boxing record. For a list of León's best fights, refer to "Best fights of Daniel Ponce de León".
On June 7, 2014 Daniel Ponce de León faced off against Miguel Roman in a super-featherweight bout at age 33. He was coming in with a record of 45-7 (35), and Roman was 28 years old and with a record of 45-11 (34). León lost the fight via 9th-round TKO.
On March 15, 2014 Daniel Ponce de León faced off against Juan Manuel López in a super-featherweight bout at age 33. He was coming in with a record of 45-6 (35), and López was 30 years old and with a record of 33-3 (30). León lost the fight via 2nd-round TKO.
On May 4, 2013 Daniel Ponce de León met Abner Mares in a featherweight (WBC) world-title defense fight. León was 32 years old and with a record of 44-5 (35), and Mares was 27 years old and with a record of 25-0-1 (13). León lost the fight via 9th-round TKO and lost the title.
On September 10, 2011 Daniel Ponce de León faced off against Yuriorkis Gamboa in a super-featherweight bout at age 31. He was coming in with a record of 41-4 (34), and Gamboa was 29 years old and with a record of 20-0 (16). León lost the fight via 8-round technical decision.
On March 5, 2011 Daniel Ponce de León faced off against Adrien Broner in a super-featherweight bout at age 30. He was coming in with a record of 41-3 (34), and Broner was 21 years old and with a record of 19-0 (16). León lost the fight via 10-round unanimous decision.
On June 7, 2008 Daniel Ponce de León met Juan Manuel López in a super-bantamweight (WBO) world-title defense fight. León was 27 years old and with a record of 34-2 (30), and López was 24 years old and with a record of 21-0 (19). León lost the fight via 1st-round TKO and lost the title.
On February 17, 2005 Daniel Ponce de León faced off against Celestino Caballero in a super-bantamweight bout at age 24. He was coming in with a record of 24-1 (23), and Caballero was 28 years old and with a record of 20-2 (15). León lost the fight via 12-round unanimous decision.