Daniel Jacobs has five losses against five opponents on his boxing record. For a list of Jacobs's best fights, refer to "Best fights of Daniel Jacobs".
On July 6, 2024 Daniel Jacobs faced off against Shane Mosley Jr. in a super-middleweight bout at age 37. He was coming in with a record of 37-5 (30), and Mosley Jr. was 32 years old and with a record of 21-4 (12). Jacobs lost the fight via 10-round unanimous decision.
On February 12, 2022 Daniel Jacobs faced off against John Ryder at age 35. He was coming in with a record of 37-4 (30), and Ryder was 33 years old and with a record of 30-5 (17). Jacobs lost the fight via 12-round split decision.
On May 4, 2019 Daniel Jacobs, the IBF champion, met Canelo Álvarez, the WBA (Super), WBC and The Ring champion, in a middleweight world-title unification fight. Jacobs was 32 years old and with a record of 35-3 (29), and Álvarez was 28 years old and with a record of 51-1-2 (35). Jacobs lost the fight via 12-round unanimous decision and lost his title.
On March 18, 2017 Daniel Jacobs fought Gennady Golovkin in a middleweight world-title fight for Golovkin's WBA (Super) and WBC titles. Jacobs was 30 years old and with a record of 32-2 (29), and Golovkin was 34 years old and with a record of 36-0 (33). Jacobs lost the fight via 12-round unanimous decision.
On July 31, 2010 Daniel Jacobs fought Dmitry Pirog in a middleweight world-title fight for the WBO title. Jacobs was 23 years old and with a record of 20-1 (17), and Pirog was 30 years old and with a record of 16-0 (13). Jacobs lost the fight via 5th-round KO.