Daniel Dubois has three losses against two opponents on his boxing record. For a list of Dubois's best fights, refer to "Best fights of Daniel Dubois".
On July 19, 2025 Daniel Dubois, the IBF champion, met Oleksandr Usyk, the WBA (Super), WBC, WBO and The Ring champion, in a heavyweight world-title unification fight. Dubois was 27 years old and with a record of 22-3 (21), and Usyk was 38 years old and with a record of 23-0 (14). Dubois lost the fight via 5th-round KO and lost his title.
On August 26, 2023 Daniel Dubois fought Oleksandr Usyk in a heavyweight world-title fight for Usyk's WBA (Super), IBF, WBO and The Ring titles. Dubois was 25 years old and with a record of 19-2 (18), and Usyk was 36 years old and with a record of 20-0 (13). Dubois lost the fight via 9th-round KO.
On November 28, 2020 Daniel Dubois faced off against Joe Joyce in a heavyweight bout at age 23. He was coming in with a record of 15-1 (14), and Joyce was 35 years old and with a record of 11-0 (10). Dubois lost the fight via 10th-round KO.