Chris John has one loss against one opponent on his boxing record. For a list of John's best fights, refer to "Best fights of Chris John".
On December 6, 2013 Chris John met Simpiwe Vetyeka in a featherweight () world-title defense fight. John was 34 years old and with a record of 48-1-3 (22), and Vetyeka was 32 years old and with a record of 25-2 (15). John lost the fight via 6th-round retirement and lost the titles.
