Chris Byrd has five losses against four opponents on his boxing record. For a list of Byrd's best fights, refer to "Best fights of Chris Byrd".
On May 16, 2008 Chris Byrd faced off against Shaun George at age 37. He was coming in with a record of 40-5-1 (21). Byrd lost the fight via 9th-round TKO.
On October 27, 2007 Chris Byrd faced off against Alexander Povetkin at age 37. He was coming in with a record of 40-4-1 (21), and Povetkin was 28 years old and with a record of 13-0 (10). Byrd lost the fight via 11th-round TKO.
On April 22, 2006 Chris Byrd met Wladimir Klitschko in a heavyweight () world-title defense fight. Byrd was 35 years old and with a record of 39-3-1 (20), and Klitschko was 30 years old and with a record of 45-3 (39). Byrd lost the fight via 7th-round TKO and lost the titles.
On October 14, 2000 Chris Byrd met Wladimir Klitschko in a heavyweight (WBO) world-title defense fight. Byrd was 30 years old and with a record of 31-2 (19), and Klitschko was 24 years old and with a record of 34-1 (31). Byrd lost the fight via 12-round unanimous decision and lost the title.
On March 20, 1999 Chris Byrd faced off against Ike Ibeabuchi at age 28. He was coming in with a record of 26-1 (14), and Ibeabuchi was 26 years old and with a record of 19-0 (14). Byrd lost the fight via 5th-round TKO.
