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Daniel Ponce de León had a total of seven losses in his professional boxing career — two of them in title bouts and five in non-title bouts. He suffered his first loss against Celestino Caballero via 12 round unanimous decision on February 17, 2005, which ended his 24-fight win streak. He has been stopped four times and lost three times via decision.
Miguel Roman, Abner Mares, Yuriorkis Gamboa, Adrien Broner, and Juan Manuel López are some of the boxers who have beaten León.
This is the first loss in Daniel Ponce de León's career. León lost to Panamanian boxer Celestino Caballero via 12 round unanimous decision on in a non-title bout. He was 24 years old with a record of 24-0. Caballero was 28 years old with a record of 20-2.
On León lost to Puerto Rican boxer Juan Manuel López via 1st round TKO. He was defending his super-bantamweight WBO title, he was 27 years old with a record of 34-1. López was 24 years old with a record of 21-0.
On León lost to American boxer Adrien Broner via 10 round unanimous decision in a non-title bout. He was 30 years old with a record of 41-2. Broner was 21 years old with a record of 19-0.
On León lost to Cuban boxer Yuriorkis Gamboa via 8 round technical decision in a non-title bout. He was 31 years old with a record of 41-3. Gamboa was 29 years old with a record of 20-0.
On León lost to fellow Mexican boxer Abner Mares via 9th round TKO. He was defending his featherweight WBC title, he was 32 years old with a record of 44-4. Mares was 27 years old with a record of 25-0-1.
On León lost to Puerto Rican boxer Juan Manuel López in a rematch via 2nd round TKO in a non-title bout. He was 33 years old with a record of 45-5. López was 30 years old with a record of 33-3.
On León lost to Miguel Roman via 9th round TKO in a non-title bout. He was 33 years old with a record of 45-6.