Here is a list of Griffin's best fights. For a list of Griffin's losses, refer to "Otis Griffin Losses".
On May 7, 2010 Otis Griffin faced off against Byron Mitchell in a light-heavyweight bout at age 32. He was coming in with a record of 22-6-2 (9), and Mitchell was 36 years old and with a record of 28-5-1 (21). Griffin stopped Byron Mitchell via TKO.