Miguel Cotto has six losses against six opponents on his boxing record. For a list of Cotto's best fights, refer to "Best fights of Miguel Cotto".
On December 2, 2017 Miguel Cotto met Sadam Ali in a super-welterweight (WBO) world-title defense fight. Cotto was 37 years old and with a record of 41-6 (33), and Ali was 29 years old and with a record of 25-1 (14). Cotto lost the fight via 12-round unanimous decision and lost the title.
On November 21, 2015 Miguel Cotto met Canelo Álvarez in a middleweight (The Ring) world-title defense fight. Cotto was 35 years old and with a record of 40-5 (33), and Álvarez was 25 years old and with a record of 45-1-1 (32). Cotto lost the fight via 12-round unanimous decision and lost the title.
On December 1, 2012 Miguel Cotto fought Austin Trout in a super-welterweight world-title fight for Trout's WBA (Regular) title. Cotto was 32 years old and with a record of 37-4 (30), and Trout was 27 years old and with a record of 25-0 (14). Cotto lost the fight via 12-round unanimous decision.
On May 5, 2012 Miguel Cotto met Floyd Mayweather Jr. in a super-welterweight (WBA (Super)) world-title defense fight. Cotto was 31 years old and with a record of 37-3 (30), and Mayweather Jr. was 35 years old and with a record of 42-0 (26). Cotto lost the fight via 12-round unanimous decision and lost the title.
On November 14, 2009 Miguel Cotto met Manny Pacquiao in a welterweight (WBO) world-title defense fight. Cotto was 29 years old and with a record of 34-2 (27), and Pacquiao was 30 years old and with a record of 49-3-2 (37). Cotto lost the fight via 12th-round TKO and lost the title.
On July 26, 2008 Miguel Cotto met Antonio Margarito in a welterweight (WBA) world-title defense fight. Cotto was 27 years old and with a record of 32-1 (26), and Margarito was 30 years old and with a record of 36-5 (26). Cotto lost the fight via 11th-round TKO and lost the title.