René Santiago was born in Humacao, Puerto Rico on April 10, 1992. He made his professional debut at the age of 22 years on November 22, 2014 against Gustavo Ortiz. Santiago defeated Ortiz via 4-round unanimous decision, making a successful beginning of his pro career.
Santiago got his first shot at a world title at the age of 31 after 15 professional fights. On March 2, 2024 Santiago challenged Jonathan González' WBO light-flyweight title but lost via 12-round unanimous decision.
He became a world champion on March 13, 2025 at the age of 32 years, after by defeating Shokichi Iwata, the then-reining WBO light-flyweight champion, via 12-round unanimous decision. This was his 18th fight as a professional.
Santiago's latest fight was a unanimous decision victory over Shokichi Iwata at age 32, on March 13, 2025, in which he won the WBO light-flyweight world title.
Some of René Santiago's best fights so far have been against Shokichi Iwata. For a top-10 list of Santiago's best performances, refer to "Best fights of René Santiago".
Santiago has 4 losses on his record. For details about these losses refer to "René Santiago Losses".
# | Date | Age | Opponent | Res | Via |
---|---|---|---|---|---|
18 | Mar 13, 2025 | 32 | ![]() | win | UD 12 |
17 | Oct 30, 2024 | 32 | ![]() | win | UD 12 |
16 | Mar 02, 2024 | 31 | ![]() | loss | UD 12 |
15 | Oct 27, 2023 | 31 | ![]() | win | KO 12 |
14 | Apr 14, 2023 | 31 | ![]() | win | TKO 9 |
13 | Dec 16, 2022 | 30 | ![]() | win | DQ 2 |
12 | Apr 08, 2022 | 29 | ![]() | loss | UD 10 |
11 | Nov 07, 2021 | 29 | ![]() | win | TKO 2 |
10 | Jan 31, 2020 | 27 | ![]() | win | UD 10 |
9 | Nov 23, 2019 | 27 | ![]() | win | TKO 1 |
8 | Dec 07, 2018 | 26 | ![]() | loss | UD 6 |
7 | Aug 25, 2018 | 26 | ![]() | win | TKO 2 |
6 | Jul 01, 2018 | 26 | ![]() | win | KO 1 |
5 | Jan 30, 2016 | 23 | ![]() | loss | UD 6 |
4 | Aug 22, 2015 | 23 | ![]() | win | TKO 2 |
3 | May 31, 2015 | 23 | ![]() | win | TKO 3 |
2 | Apr 25, 2015 | 23 | ![]() | win | TKO 2 |
1 | Nov 22, 2014 | 22 | ![]() | win | UD 4 |