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Brian Castaño has had just a single loss inhis professional boxing career so far. He suffered his first loss against Jermell Charlo via 10th round KO on May 14, 2022, which ended his 17-fight win streak. Charlo is the only boxer to beat Castaño.
The first and only loss in Brian Castaño's career so far. Castaño lost to American boxer Jermell Charlo in the rematch via 10th round KO on . He was defending his super-welterweight WBO title, and fighting for Charlo's super-welterweight WBA (Super), WBC, IBF, and The Ring titles, he was 32 years old with a record of 17-0-2. Charlo was 31 years old with a record of 34-1-1.