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Antonio Orozco had a total of two losses in his professional boxing career — one of them in a title bout and one in a non-title bout. He suffered his first loss against José Carlos Ramírez via 12 round unanimous decision on September 14, 2018, which ended his 27-fight win streak. He has been stopped once and lost once via decision.
Vergil Ortiz Jr. and José Carlos Ramírez are the two boxers who have beaten Orozco.
This is the first loss in Antonio Orozco's career. Orozco lost to José Carlos Ramírez via 12 round unanimous decision on . He was fighting for Ramírez' super-lightweight WBC title, he was 30 years old with a record of 27-0.
On Orozco lost to American boxer Vergil Ortiz Jr. via 6th round KO in a non-title bout. He was 31 years old with a record of 28-1. Ortiz Jr. was 21 years old with a record of 13-0.