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Simpiwe Vetyeka had a total of four losses in his professional boxing career — two of them in title bouts and two in non-title bouts. He suffered his first loss against Hozumi Hasegawa via 12 round unanimous decision on May 3, 2007, which ended his 16-fight win streak. He has never been stopped, all his losses came via decision.
Lerato Dlamini, Nonito Donaire, Klaas Mboyane, and Hozumi Hasegawa are the four boxers who have beaten Vetyeka.
This is the first loss in Simpiwe Vetyeka's career. Vetyeka lost to Japanese boxer Hozumi Hasegawa via 12 round unanimous decision on . He was fighting for Hasegawa's bantamweight WBC title, he was 26 years old with a record of 16-0. Hasegawa was also 26 years old, with a record of 21-2.
On Vetyeka lost to Klaas Mboyane via 8 round split decision in a non-title bout. He was 31 years old with a record of 23-1.
On Vetyeka lost to Filipino boxer Nonito Donaire via 5 round technical decision. He was defending his featherweight WBA (Undisputed) title, he was 33 years old with a record of 26-2. Donaire was 31 years old with a record of 32-2.
On Vetyeka lost to Lerato Dlamini via 10 round majority decision in a non-title bout. He was 36 years old with a record of 29-3.