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Léo Santa Cruz has had a total of two losses in his professional boxing career so far — both of them in title bouts. He suffered his first loss against Carl Frampton via 12 round majority decision on July 30, 2016, which ended his 32-fight win streak. He has been stopped once and lost once via decision.
Gervonta Davis and Carl Frampton are the two boxers who have beaten Cruz.
This is the first loss in Léo Santa Cruz' career. Cruz lost to Irish boxer Carl Frampton via 12 round majority decision on . He was defending his featherweight WBA (Super) title, he was 27 years old with a record of 32-0-1. Frampton was 29 years old with a record of 22-0.
On Cruz lost to American boxer Gervonta Davis via 6th round KO. He was defending his super-featherweight WBA (Super) title, and fighting for Davis' super-featherweight WBA (Regular) title, he was 32 years old with a record of 37-1-1. Davis was 25 years old with a record of 23-0.