Jose Zepeda has had a total of three losses in his professional boxing career so far — all of them in title bouts. He suffered his first loss against Terry Flanagan via 2nd round RTD on July 11, 2015, which ended his 23-fight win streak. He has been stopped two times and lost once via decision.
Regis Prograis, José Ramírez, and Terry Flanagan are the three boxers who have beaten Zepeda.
This is the first loss in Jose Zepeda's career. Zepeda lost to British boxer Terry Flanagan via 2nd round RTD on . He and Flanagan were fighting for the vacant lightweight WBO title. He was 26 years old with a record of 23-0. Flanagan was also 26 years old, with a record of 27-0.
On Zepeda lost to José Ramírez via 12 round majority decision. He was fighting for Ramírez' super-lightweight WBC title, he was 29 years old with a record of 30-1. Ramírez was 26 years old with a record of 23-0.
On Zepeda lost to Regis Prograis via 11th round KO. He and Prograis were fighting for the vacant super-lightweight WBC title. He was 33 years old with a record of 35-2. Prograis was also 33 years old, with a record of 27-1.