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Fernando Vargas had a total of five losses in his professional boxing career — two of them in title bouts and three in non-title bouts. He suffered his first loss against Félix Trinidad via 12th round TKO on December 2, 2000, which ended his 20-fight win streak. He has been stopped four times and lost once via decision.
Ricardo Mayorga, Shane Mosley, Oscar De La Hoya, and Félix Trinidad are the four boxers who have beaten Vargas.
This is the first loss in Fernando Vargas' career. Vargas lost to Puerto Rican boxer Félix Trinidad via 12th round TKO on . He was defending his super-welterweight IBF title, and fighting for Trinidad's super-welterweight WBA title, he was 22 years old with a record of 20-0. Trinidad was 27 years old with a record of 38-0.
On Vargas lost to Oscar De La Hoya via 11th round TKO. He was defending his super-welterweight WBA title, and fighting for De La Hoya's super-welterweight WBC and The Ring titles and the vacant WBA (Super) title He was 24 years old with a record of 22-1. De La Hoya was 29 years old with a record of 34-2.
On Vargas lost to Shane Mosley via 10th round TKO in a non-title bout. He was 28 years old with a record of 26-2. Mosley was 34 years old with a record of 41-4.
On Vargas lost to Shane Mosley in the rematch via 6th round TKO in a non-title bout. He was 28 years old with a record of 26-3. Mosley was 34 years old with a record of 42-4.
On Vargas lost to Nicaraguan boxer Ricardo Mayorga via 12 round majority decision in a non-title bout. He was 29 years old with a record of 26-4. Mayorga was 34 years old with a record of 27-6-1.