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David Kamau had a total of four losses in his professional boxing career — two of them in title bouts and two in non-title bouts. He suffered his first loss against Julio Cesar Chavez via 12 round unanimous decision on September 16, 1995, which ended his 26-fight win streak. He has been stopped two times and lost two times via decision.
Antonio Margarito, Danny Perez, Oscar De La Hoya, and Julio Cesar Chavez are the four boxers who have beaten Kamau.
This is the first loss in David Kamau's career. Kamau lost to Mexican boxer Julio Cesar Chavez via 12 round unanimous decision on . He was fighting for Chavez' super-lightweight WBC title, he was 30 years old with a record of 26-0. Chávez was 33 years old with a record of 94-1-1.
On Kamau lost to American boxer Oscar De La Hoya via 2nd round KO. He was fighting for De La Hoya's welterweight WBC title, he was 31 years old with a record of 28-1. De La Hoya was 24 years old with a record of 24-0.
On Kamau lost to Danny Perez in a rematch via 8 round majority decision in a non-title bout. He was 33 years old with a record of 28-2.
On Kamau lost to Mexican boxer Antonio Margarito via 2nd round TKO in a non-title bout. He was 34 years old with a record of 30-3. Margarito was 22 years old with a record of 21-3.