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Andre Dirrell has had a total of three losses in his professional boxing career so far — two of them in title bouts and one in a non-title bout. He suffered his first loss against Carl Froch via 12 round split decision on October 17, 2009, which ended his 18-fight win streak. He has been stopped once and lost two times via decision.
José Uzcátegui, James DeGale, and Carl Froch are the three boxers who have beaten Dirrell.
This is the first loss in Andre Dirrell's career. Dirrell lost to British boxer Carl Froch via 12 round split decision on . He was fighting for Froch's super-middleweight WBC title, he was 26 years old with a record of 18-0. Froch was 32 years old with a record of 25-0.
On Dirrell lost to British boxer James DeGale via 12 round unanimous decision. He and DeGale were fighting for the vacant super-middleweight IBF title. He was 31 years old with a record of 24-1. DeGale was 29 years old with a record of 20-1.
On Dirrell lost to Venezuelan boxer José Uzcátegui in the rematch via 8th round RTD in a non-title bout. He was 34 years old with a record of 26-2. Uzcátegui was 27 years old with a record of 26-2.