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Daniel Jacobs has had a total of four losses in his professional boxing career so far — three of them in title bouts and one in a non-title bout. He suffered his first loss against Dmitry Pirog via 5th round KO on July 31, 2010, which ended his 20-fight win streak. He has been stopped once and lost three times via decision.
John Ryder, Canelo Álvarez, Gennady Golovkin, and Dmitry Pirog are the four boxers who have beaten Jacobs.
This is the first loss in Daniel Jacobs' career. Jacobs lost to Russian boxer Dmitry Pirog via 5th round KO on . He and Pirog were fighting for the vacant middleweight WBO title. He was 23 years old with a record of 20-0. Pirog was 30 years old with a record of 16-0.
On Jacobs lost to Kazakhstani boxer Gennady Golovkin via 12 round unanimous decision. He was fighting for Golovkin's middleweight WBA (Super) and WBC titles, he was 30 years old with a record of 32-1. Golovkin was 34 years old with a record of 36-0.
On Jacobs lost to Mexican boxer Canelo Álvarez via 12 round unanimous decision. He was defending his middleweight IBF title, and fighting for Álvarez' middleweight WBA (Super), WBC, and The Ring titles, he was 32 years old with a record of 35-2. Canelo was 28 years old with a record of 51-1-2.
On Jacobs lost to British boxer John Ryder via 12 round split decision in a non-title bout. He was 35 years old with a record of 37-3. Ryder was 33 years old with a record of 30-5.