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Carlos Quintana had a total of four losses in his professional boxing career — three of them in title bouts and one in a non-title bout. He suffered his first loss against Miguel Cotto via 5th round RTD on December 2, 2006, which ended his 23-fight win streak. All of Quintana's losses came via stoppage.
Keith Thurman, Andre Berto, Paul Williams, and Miguel Cotto are the four boxers who have beaten Quintana.
This is the first loss in Carlos Quintana's career. Quintana lost to fellow Puerto Rican boxer Miguel Cotto via 5th round RTD on . He and Cotto were fighting for the vacant welterweight WBA title. He was 30 years old with a record of 23-0. Cotto was 26 years old with a record of 27-0.
On Quintana lost to American boxer Paul Williams in the rematch via 1st round TKO. He was defending his welterweight WBO title, he was 31 years old with a record of 25-1. Williams was 26 years old with a record of 33-1.
On Quintana lost to American boxer Andre Berto via 8th round TKO. He was fighting for Berto's welterweight WBC title, he was 33 years old with a record of 27-2. Berto was 26 years old with a record of 25-0.
On Quintana lost to American boxer Keith Thurman via 4th round TKO in a non-title bout. He was 36 years old with a record of 29-3. Thurman was 24 years old with a record of 18-0.